Details:

3BNC117

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:3BNC117 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 4JPV

3D Structure Viewer: 4JPV 4LSV
Donor:Patient 3Best neutralization breadth IC50, %:92*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:21764753Best neutralization potency (in μg/ml):0.06*
# of studies in bNAber:4Polyreactivity:Yes
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang201396*90*75*100*NANA94*89*85*
Scheid2011100*100*92*100*NA86*100*100*92*
Georgiev2013100*90*79*100*NANA100*100*89*
Huang201497*90*76*100*NANA94*81*84*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang20130.03*0.07*0.11*0.17*NANA0.06*0.04*0.07*
Scheid20110.01*0.05*0.22*0.17*NA0.26*0.17*0.11*0.09*
Georgiev20130.03*0.06*0.07*0.24*NANA0.06*0.03*0.06*
Huang20140.03*0.07*0.11*0.17*NANA0.06*0.05*0.07*
Sequence Information:
Heavy Chain
PutativeVgeneIGVH1-2
PutativeJgeneIGHJ2/6
CDR3 length aa12
CDR3sequence aaARQRSDYWDFDV
Somatic mutations aa34
Somatic mutations na76 (77)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV1D-33
PutativeJgeneIGKJ3
CDR3 length aa5
CDR3sequence aaCQVYEFV
Somatic mutations na20 (22)
Somatic mutations aa41 (44)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
4JPV4LSV
GenBankLight Chain AA: HE584538 Light Chain DNA: HE584538
Heavy Chain AA: HE584537 Heavy Chain DNA: HE584537

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database