bNAb: | 3BNC117 - XML Export | Alternate Names: | No alternate names known | Representative Structure: 4JPV
 3D Structure Viewer: 4JPV 4LSV |
Donor: | Patient 3 | Best neutralization breadth IC50, %: | 92* |
Binding Site: | CD4bs | Neutralization breadth IC80, %: | NA |
Primary Reference: | 21764753 | Best neutralization potency (in μg/ml): | 0.06* |
# of studies in bNAber: | 4 | Polyreactivity: | Yes |
Competition of bNAbs with sCD4 and bNAbs in ELISA: |
sCD4 | b12 | a2G12 | F425 | X5 | PG9 | PGT121 | PGT125 | PGT130 | PGT135 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
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Percent viruses neutralized with an IC50 < 50 μg/ml: |
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Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml: |
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Sequence Information: | Heavy Chain | PutativeVgene | IGVH1-2 | PutativeJgene | IGHJ2/6 | CDR3 length aa | 12 | CDR3sequence aa | ARQRSDYWDFDV | Somatic mutations aa | 34 | Somatic mutations na | 76 (77) | Mutation frequency na | | Mutation frequency aa | | InsertionDeletions aa pos | |
| Light Chain | PutativeVgene | IGKV1D-33 | PutativeJgene | IGKJ3 | CDR3 length aa | 5 | CDR3sequence aa | CQVYEFV | Somatic mutations na | 20 (22) | Somatic mutations aa | 41 (44) | Mutation frequency na | | Mutation frequency aa | | InsertionDeletions aa pos | |
| Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs. |
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External Resources: |
EMDataBank | NA |
PDB | 4JPV4LSVGenBank | Light Chain AA: HE584538 Light Chain DNA: HE584538 Heavy Chain AA: HE584537 Heavy Chain DNA: HE584537 | |