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What is the proposed germline of a bNAb?
What are bNAb sequence characteristics?
Heavy Chain
Light Chain
Neutralization IC50 of bNAb X with virus isolate Y
Neutralizing activity of multiple bNAb against selected HIV isolate or subtype
Residues important for neutralization by bNAb
Neutralizing activity of bNAb against a panel of JR-CSF alanine mutants
bNAb structure solved
HIV-1 isolates sequences (LANL HIV sequence database)
Neutralization IC50 profile for bNAb(s)
Median ICs and percent viruses neutralized with an IC50 < 50 μg/ml
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml
Percent viruses neutralized with an IC50 < 50 μg/ml
Median IC50 (μg/ml) against all viruses
Competition of bNAb with sCD4 and bNAb in ELISA
Summary of Best Neutralizing Antibodies from LANL HIV Database