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Biologist View

  • What is the proposed germline of a bNAb?
  • What are bNAb sequence characteristics?
    • Heavy Chain
    • Light Chain
  • Neutralization IC50 of bNAb X with virus isolate Y
  • Neutralizing activity of multiple bNAb against selected HIV isolate or subtype
  • Residues important for neutralization by bNAb
  • Neutralizing activity of bNAb against a panel of JR-CSF alanine mutants
  • bNAb structure solved
  • HIV-1 isolates sequences (LANL HIV sequence database)
  • Neutralization IC50 profile for bNAb(s)
  • Median ICs and percent viruses neutralized with an IC50 < 50 μg/ml
    • Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml
    • Percent viruses neutralized with an IC50 < 50 μg/ml
    • Median IC50 (μg/ml) against all viruses
  • Competition of bNAb with sCD4 and bNAb in ELISA
  • Summary of Best Neutralizing Antibodies from LANL HIV Database
www.bNAber.org | 2013 | | A member of | Page accessed on June 24, 2017, 5:04 AM | Contact Us
bNAber is a database, analysis, visualization, and data discovery tool for broadly neutralizing HIV-1 antibodies (bNAbs), and seeks to be a vital tool in the search for an AIDS vaccine.