Discovery of Broadly Neutralizing Antibodies (bNAbs) has given a great boost to HIV vaccine research. Study of bNAbs capable of neutralizing a broad array of different HIV strains is important for a number of reasons: (i) structures of antigens co-crystallized with bNAbs are used as templates in HIV vaccine design; (ii) bNAbs can be effective as therapeutics; (iii) preventive use of bNAbs is a promising direction in AIDS care. The goal of bNAber is to collect, analyze, compare and present bNAbs data, thus helping researchers to create HIV vaccine.
Search for anti-HIV bNAbs that fit the following criteria. All criteria are combined to create the resulting dataset.
Select Ab based on gp160 biding site:
Image used with permission from Cell Host Microbe.
bNAber computes on the fly the percent viruses neutralized with an IC50 < 50 μg/ml and median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml. The value that were computed on the fly are indicated with asterisk (*) on bNAb Details Page. Clicking on these values brings you original neutralization data from publication.
Blast search is available
A new service has been added to bNAber: now you can do blast search to find sequence similarity with bNAbs in the database (H- and L-chains, both nucleotide or amino acids). Just click on the BLAST tab. New interface will give a compact presentation of blast results.
Two more instructional videos have been added to bNAber video collection:
How to build neutralization heatmaps in bNAber and
How to compare bNAbs sequences and structures (1D and 3D)
Click here to view the video tutorials
bNAbs to Flu
Recently, discovery of broadly neutralizing antibodies to influenza virus has identified two major supersites of vulnerability on the influenza virus hemagglutinin, one involved in receptor binding and the other, in fusion machinery.
3BNC117 first-in-man trial
Antibody-based drug against HIV was for the first time tested in humans – see here.
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bNAber is a database, analysis, visualization, and data discovery tool for broadly neutralizing HIV-1 antibodies (bNAbs), and seeks to be a vital tool in the search for an AIDS vaccine.